Scientific publications Archives - Prosilico https://prosilico.com/category/scientific-publications/ Delivering high quality in silico estimates of human ADME/PK Mon, 22 May 2023 12:08:01 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.1 https://prosilico.com/wp-content/uploads/2022/03/cropped-favicon-32x32.png Scientific publications Archives - Prosilico https://prosilico.com/category/scientific-publications/ 32 32 In silico predictions of the hepatic metabolic clearance in humans for 10 drugs with highly variable in vitro pharmacokinetics https://prosilico.com/in-silico-predictions-of-the-hepatic-metabolic-clearance-in-humans-for-10-drugs-with-highly-variable-in-vitro-pharmacokinetics/ Mon, 22 May 2023 12:08:01 +0000 https://prosilico.com/?p=1152 The post In silico predictions of the hepatic metabolic clearance in humans for 10 drugs with highly variable in vitro pharmacokinetics appeared first on Prosilico.

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Fagerholm U. In silico predictions of the hepatic metabolic clearance in humans for 10 drugs with highly variable in vitro pharmacokinetics. bioRxiv, April 2023.https://www.biorxiv.org/content/10.1101/2023.04.01.535222v1

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]]> Application of the ANDROMEDA software for prediction of the human pharmacokinetics of modern anticancer drugs https://prosilico.com/application-of-the-andromeda-software-for-prediction-of-the-human-pharmacokinetics-of-modern-anticancer-drugs/ Mon, 22 May 2023 11:58:47 +0000 https://prosilico.com/?p=1149 The post Application of the ANDROMEDA software for prediction of the human pharmacokinetics of modern anticancer drugs appeared first on Prosilico.

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Fagerholm U, Hellberg S, Alvarsson J, Spjuth O. bioRxiv, March 2023.https://www.biorxiv.org/content/10.1101/2023.03.18.533259v1

The post Application of the ANDROMEDA software for prediction of the human pharmacokinetics of modern anticancer drugs appeared first on Prosilico.

]]> Prediction of the human pharmacokinetics of 30 modern antibiotics using the ANDROMEDA software https://prosilico.com/prediction-of-the-human-pharmacokinetics-of-30-modern-antibiotics-using-the-andromeda-software/ Mon, 22 May 2023 11:54:01 +0000 https://prosilico.com/?p=1146 The post Prediction of the human pharmacokinetics of 30 modern antibiotics using the ANDROMEDA software appeared first on Prosilico.

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Fagerholm U, Hellberg S, Alvarsson J, Spjuth O. bioRxiv, March 2023.https://www.biorxiv.org/content/10.1101/2023.03.28.534601v1

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]]> In silico prediction of human clinical pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an established benchmarking data set, a modern small drug data set, and a comparison with laboratory methods https://prosilico.com/https-journals-sagepub-com-doi-abs-10-1177-02611929221148447journalcodeatla/ Tue, 21 Mar 2023 08:52:56 +0000 https://prosilico.com/?p=1133 The post In silico prediction of human clinical pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an established benchmarking data set, a modern small drug data set, and a comparison with laboratory methods appeared first on Prosilico.

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Fagerholm, Hellberg, Alvarsson, Spjuth. Altern Lab Anim. 51:39-54, 2023. https://journals.sagepub.com/doi/abs/10.1177/02611929221148447?journalCode=atla

The post In silico prediction of human clinical pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an established benchmarking data set, a modern small drug data set, and a comparison with laboratory methods appeared first on Prosilico.

]]> Comparing in silico and in vitro methods for classification of BCS II and CYP3A4 and MDR-1 substrate specificity https://prosilico.com/https-www-biorxiv-org-content-10-1101-2022-12-13-520246v1/ Tue, 21 Mar 2023 08:50:11 +0000 https://prosilico.com/?p=1131 The post Comparing in silico and in vitro methods for classification of BCS II and CYP3A4 and MDR-1 substrate specificity appeared first on Prosilico.

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Fagerholm. BioRxiv December 15, 2022.https://www.biorxiv.org/content/10.1101/2022.12.13.520246v1

The post Comparing in silico and in vitro methods for classification of BCS II and CYP3A4 and MDR-1 substrate specificity appeared first on Prosilico.

]]> Predicting the influence of fat food intake on the absorption and systemic exposure of modern small drugs using ANDROMEDA by Prosilico software https://prosilico.com/https-www-biorxiv-org-content-10-1101-2022-12-05-519072v1/ Tue, 21 Mar 2023 08:44:26 +0000 https://prosilico.com/?p=1127 The post Predicting the influence of fat food intake on the absorption and systemic exposure of modern small drugs using ANDROMEDA by Prosilico software appeared first on Prosilico.

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Fagerholm, Hellberg, Alvarsson, Spjuth. BioRxiv December 8, 2022.https://www.biorxiv.org/content/10.1101/2022.12.05.519072v1

The post Predicting the influence of fat food intake on the absorption and systemic exposure of modern small drugs using ANDROMEDA by Prosilico software appeared first on Prosilico.

]]> Evaluation of the reliability and applicability of human unbound brain-to-plasma concentration ratios https://prosilico.com/evaluation-of-the-reliability-and-applicability-of-human-unbound-brain-to-plasma-concentration-ratios/ Mon, 21 Nov 2022 11:26:13 +0000 https://prosilico.com/?p=1123 The post Evaluation of the reliability and applicability of human unbound brain-to-plasma concentration ratios appeared first on Prosilico.

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Fagerholm. BioRxiv November 21, 2022.https://www.biorxiv.org/content/10.1101/2022.11.14.516429v1

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]]> Validation of predicted conformal intervals for prediction of human clinical pharmacokinetics https://prosilico.com/validation-of-predicted-conformal-intervals-for-prediction-of-human-clinical-pharmacokinetics/ Mon, 14 Nov 2022 11:15:22 +0000 https://prosilico.com/?p=1121 The post Validation of predicted conformal intervals for prediction of human clinical pharmacokinetics appeared first on Prosilico.

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Fagerholm, Alvarsson, Hellberg, Spjuth. BioRxiv November 14, 2022.
https://www.biorxiv.org/content/10.1101/2022.11.10.515917v1

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]]> ANDROMEDA by Prosilico software successfully predicts human clinical pharmacokinetics of 70 drugs out of reach for in vitro methods https://prosilico.com/https-www-biorxiv-org-content-10-1101-2022-10-05-511015v1/ Mon, 10 Oct 2022 06:58:10 +0000 https://prosilico.com/?p=1114 The post ANDROMEDA by Prosilico software successfully predicts human clinical pharmacokinetics of 70 drugs out of reach for in vitro methods appeared first on Prosilico.

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Fagerholm, Hellberg, Alvarsson, Spjuth. BioRxiv October 7, 2022.
https://www.biorxiv.org/content/10.1101/2022.10.05.511015v1

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]]> Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix https://prosilico.com/prediction-and-classification-of-the-uptake-and-disposition-of-antidepressants-and-new-cns-active-drugs-in-the-human-brain-using-the-andromeda-by-prosilico-software-and-brainavailability-matrix/ Mon, 03 Oct 2022 09:59:51 +0000 https://prosilico.com/?p=1104 The post Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix appeared first on Prosilico.

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Fagerholm, Hellberg, Alvarsson, Spjuth. BioRxiv September 30, 2022.
https://www.biorxiv.org/content/10.1101/2022.09.28.509936v1

The post Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix appeared first on Prosilico.

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