The Company

PROSILICO is a Swedish company, founded in July 2014, focusing on the research and development of innovative technologies to provide high quality estimates of human ADME/PK (absorption, distribution, metabolism, excretion, pharmacokinetics) directly from chemical structure.

We are a highly merited team of scientists with a long experience from the pharmaceutical industry, university and IT-development, motivated by a strong and sincere willingness to drive continuous improvement and reduce and replace animal studies in research. We believe that a technology shift with significant quality improvements and replacement of many animal studies are within reach.

With our technology and support you will be able to:

  • enhance confidence and accuracy in predictions of clinical ADME/PK, exposures and doses and cost-effectiveness
  • reduce animal testing and environmental emissions
  • frontload and improve compound optimizations and decision-making

The team

Urban Fagerholm

CEO, PhD, Associate Professor in pharmacokinetics and biopharmaceutics, and model developer.

About Urban

Prosilico was founded by ex-AstraZeneca pharmacokineticist, PhD and Associate Professor in biopharmaceutics/pharmacokinetics and clinical psychologist Urban Fagerholm. He has a wide preclinical and clinical experience from 30 years in the pharmaceutical industry (AstraZeneca 1997-2013) and academia (Uppsala University), and has focused on prediction methodology, physiological models, mechanisms, analyses and strategies in the ADME/PK-field. In 2009, he was nominated International Educator of the Year and named member of Top 100 Professionals of the Year. He has published more than 40 scientific papers and book chapters and two popular science books.

Sven Hellberg

Vice CEO, PhD in computational chemistry and head of data analysis.

About Sven

Computational chemist and ex-manager in pharmaceutical R&D at AstraZeneca Sven Hellberg joined Prosilico in January 2016. Sven is highly experienced with 30+ years in QSAR, compound design and drug discovery. His skills and experiences include molecular modeling, pharmacophores, docking, structure-based design, fragment evolution, hit finding, lead identification, lead optimization, project leadership, project leader (including Lean Sigma), chemometrics, experimental design, machine learning, pattern recognition, coaching and team building. Sven a strong personal track record of delivery, and his foremost personal strengths are creativity, analytical and strategic thinking. He has been leader of the science forums for medicinal chemistry and compound design, and has excellent scientific track record with 50 scientific journal publications and 86 patent publications.

Ola Spjuth

PhD and Professor in pharmaceutical bioinformatics.

About Ola

Ola Spjuth, PhD and Associate Professor in pharmaceutical bioinformatics at Uppsala University and expert in predictive modeling and big data analysis joined Prosilico in 2018. Ola was previous co-director at the UPPMAX high performance computing center at Uppsala University, and Head of the bioinformatics compute and storage facility at Science for Life Laboratory in Sweden. He has an excellent scientific track record with more than 100 scientific publications.