Scientific publications

28 September 2022 in Scientific publications

In vitro to in vivo pharmacokinetic translation guidance

Fagerholm. BioRxiv September 28, 2022. https://www.biorxiv.org/content/10.1101/2022.09.26.509470v1
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27 September 2022 in Scientific publications

Investigation of Molecular Weights and Pharmacokinetic Characteristics of Older and Modern Small Drugs

Fagerholm. BioRxiv September 27, 2022. https://www.biorxiv.org/content/10.1101/2022.09.21.508888v1
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24 September 2022 in Scientific publications

Prediction of Biopharmaceutical Characteristics of PROTACs using the ANDROMEDA by Prosilico Software

Fagerholm, Hellberg, Alvarsson and Spjuth. BioRxiv September 24, 2022. https://www.biorxiv.org/content/10.1101/2022.09.22.509053v1
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17 August 2022 in Scientific publications

Using the ANDROMEDA by Prosilico software for prediction of the human pharmacokinetics of 4 compounds of natural origin – colistin, curucumin, UCN-01 and voclosporin

Fagerholm, Hellberg, Alvarsson and Spjuth. Biorxiv August 17, 2022. https://www.biorxiv.org/content/10.1101/2022.08.17.504228v1
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17 August 2022 in Scientific publications

In silico predictions of the gastrointestinal uptake of macrocycles in man using conformal prediction methodology

Fagerholm, Hellberg, Alvarsson and Spjuth. J Pharm Sci. May 2022. https://pubmed.ncbi.nlm.nih.gov/35605685/
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17 August 2022 in Scientific publications

The impact of reference data selection for the prediction accuracy of intrinsic hepatic metabolic clearance

Fagerholm, Spjuth and Hellberg. J Pharm Sci. July 2022. https://pubmed.ncbi.nlm.nih.gov/35793746/
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17 August 2022 in Scientific publications

In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology

Fagerholm, Hellberg, Alvarsson and Spjuth. Xenobiot. 51:1366-1371, 2022. https://www.tandfonline.com/doi/abs/10.1080/00498254.2022.2049397
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17 August 2022 in Scientific publications

Comparison between lab variability and in silico prediction errors for the unbound fraction of drugs in human plasma

Fagerholm, Spjuth & Hellberg. Xenobiot. 51:1095-1100, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.1964044
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17 August 2022 in Scientific publications

In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models

Fagerholm, Hellberg, Alvarsson, Arvidsson McShane and Spjuth. Xenobiot. 51:1366-1371, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.2011471
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17 August 2022 in Scientific publications

Advances in predictions of oral bioavailability of candidate drugs in man with new machine learning methodology

Fagerholm, Hellberg and Spjuth. Molecules 26:2572, 2021. https://pubmed.ncbi.nlm.nih.gov/33925103/
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17 August 2022 in Scientific publications

Brist på riktlinjer hindrar alternativa metoder att slå igenom

Fagerholm, Hellberg, Alsenius och Cederlöf. Debattartikel i tidningen Curie 210831. https://www.tidningencurie.se/debatt/brist-pa-riktlinjer-hindrar-alternativa-metoder-att-sla-igenom/
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17 August 2022 in Scientific publications

Authority publications about reduction of animal testing

Netherlands initiative to reduce animal testing https://english.ncadierproevenbeleid.nl/latest/news/16/12/15/ncad-opinion-transition-to-non-animal-research FDAs initiative to reduce animal testing https://www.fdanews.com/articles/182663-congress-pushes-for-in-silico-trials-modeling
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