Scientific publications

21 November 2022 in Scientific publications

Evaluation of the reliability and applicability of human unbound brain-to-plasma concentration ratios

Fagerholm. BioRxiv November 21, 2022.https://www.biorxiv.org/content/10.1101/2022.11.14.516429v1
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14 November 2022 in Scientific publications

Validation of predicted conformal intervals for prediction of human clinical pharmacokinetics

Fagerholm, Alvarsson, Hellberg, Spjuth. BioRxiv November 14, 2022. https://www.biorxiv.org/content/10.1101/2022.11.10.515917v1
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10 October 2022 in Scientific publications

ANDROMEDA by Prosilico software successfully predicts human clinical pharmacokinetics of 70 drugs out of reach for in vitro methods

Fagerholm, Hellberg, Alvarsson, Spjuth. BioRxiv October 7, 2022. https://www.biorxiv.org/content/10.1101/2022.10.05.511015v1
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3 October 2022 in Scientific publications

Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix

Fagerholm, Hellberg, Alvarsson, Spjuth. BioRxiv September 30, 2022. https://www.biorxiv.org/content/10.1101/2022.09.28.509936v1
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3 October 2022 in Scientific publications

An analysis of laboratory variability and thresholds for human in vitro ADME/PK methods

Fagerholm. BioRxiv September 28, 2022. https://www.biorxiv.org/content/10.1101/2022.09.27.509731v1
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28 September 2022 in Scientific publications

In vitro to in vivo pharmacokinetic translation guidance

Fagerholm. BioRxiv September 28, 2022. https://www.biorxiv.org/content/10.1101/2022.09.26.509470v1
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27 September 2022 in Scientific publications

Investigation of Molecular Weights and Pharmacokinetic Characteristics of Older and Modern Small Drugs

Fagerholm. BioRxiv September 27, 2022. https://www.biorxiv.org/content/10.1101/2022.09.21.508888v1
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24 September 2022 in Scientific publications

Prediction of Biopharmaceutical Characteristics of PROTACs using the ANDROMEDA by Prosilico Software

Fagerholm, Hellberg, Alvarsson and Spjuth. BioRxiv September 24, 2022. https://www.biorxiv.org/content/10.1101/2022.09.22.509053v1
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17 August 2022 in Scientific publications

Using the ANDROMEDA by Prosilico software for prediction of the human pharmacokinetics of 4 compounds of natural origin – colistin, curucumin, UCN-01 and voclosporin

Fagerholm, Hellberg, Alvarsson and Spjuth. Biorxiv August 17, 2022. https://www.biorxiv.org/content/10.1101/2022.08.17.504228v1
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17 August 2022 in Scientific publications

In silico predictions of the gastrointestinal uptake of macrocycles in man using conformal prediction methodology

Fagerholm, Hellberg, Alvarsson and Spjuth. J Pharm Sci. May 2022. https://pubmed.ncbi.nlm.nih.gov/35605685/
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17 August 2022 in Scientific publications

The impact of reference data selection for the prediction accuracy of intrinsic hepatic metabolic clearance

Fagerholm, Spjuth and Hellberg. J Pharm Sci. July 2022. https://pubmed.ncbi.nlm.nih.gov/35793746/
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17 August 2022 in Scientific publications

In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology

Fagerholm, Hellberg, Alvarsson and Spjuth. Xenobiot. 51:1366-1371, 2022. https://www.tandfonline.com/doi/abs/10.1080/00498254.2022.2049397
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17 August 2022 in Scientific publications

Comparison between lab variability and in silico prediction errors for the unbound fraction of drugs in human plasma

Fagerholm, Spjuth & Hellberg. Xenobiot. 51:1095-1100, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.1964044
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17 August 2022 in Scientific publications

In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models

Fagerholm, Hellberg, Alvarsson, Arvidsson McShane and Spjuth. Xenobiot. 51:1366-1371, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.2011471
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17 August 2022 in Scientific publications

Advances in predictions of oral bioavailability of candidate drugs in man with new machine learning methodology

Fagerholm, Hellberg and Spjuth. Molecules 26:2572, 2021. https://pubmed.ncbi.nlm.nih.gov/33925103/
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17 August 2022 in Scientific publications

Brist på riktlinjer hindrar alternativa metoder att slå igenom

Fagerholm, Hellberg, Alsenius och Cederlöf. Debattartikel i tidningen Curie 210831. https://www.tidningencurie.se/debatt/brist-pa-riktlinjer-hindrar-alternativa-metoder-att-sla-igenom/
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17 August 2022 in Scientific publications

Authority publications about reduction of animal testing

Netherlands initiative to reduce animal testing https://english.ncadierproevenbeleid.nl/latest/news/16/12/15/ncad-opinion-transition-to-non-animal-research FDAs initiative to reduce animal testing https://www.fdanews.com/articles/182663-congress-pushes-for-in-silico-trials-modeling
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