News 17 August 2022 April 27-28 2022 – PROSILICO attended 3rd Swedish Medicinal Chemistry Symposium in Stockholm PROSILICO attended 3rd Swedish Medicinal Chemistry Symposium in Stockholm April 27-28 2022 and gave pitch… Urban Fagerholm
Scientific publications 17 August 2022 Using the ANDROMEDA by Prosilico software for prediction of the human pharmacokinetics of 4 compounds of natural origin – colistin, curucumin, UCN-01 and voclosporin Fagerholm, Hellberg, Alvarsson and Spjuth. Biorxiv August 17, 2022. https://www.biorxiv.org/content/10.1101/2022.08.17.504228v1 Urban Fagerholm
Scientific publications 17 August 2022 In silico predictions of the gastrointestinal uptake of macrocycles in man using conformal prediction methodology Fagerholm, Hellberg, Alvarsson and Spjuth. J Pharm Sci. May 2022. https://pubmed.ncbi.nlm.nih.gov/35605685/ Urban Fagerholm
Scientific publications 17 August 2022 The impact of reference data selection for the prediction accuracy of intrinsic hepatic metabolic clearance Fagerholm, Spjuth and Hellberg. J Pharm Sci. July 2022. https://pubmed.ncbi.nlm.nih.gov/35793746/ Urban Fagerholm
Scientific publications 17 August 2022 In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology Fagerholm, Hellberg, Alvarsson and Spjuth. Xenobiot. 51:1366-1371, 2022. https://www.tandfonline.com/doi/abs/10.1080/00498254.2022.2049397 Urban Fagerholm
Scientific publications 17 August 2022 Comparison between lab variability and in silico prediction errors for the unbound fraction of drugs in human plasma Fagerholm, Spjuth & Hellberg. Xenobiot. 51:1095-1100, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.1964044 Urban Fagerholm
Scientific publications 17 August 2022 In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models Fagerholm, Hellberg, Alvarsson, Arvidsson McShane and Spjuth. Xenobiot. 51:1366-1371, 2021. https://www.tandfonline.com/doi/full/10.1080/00498254.2021.2011471 Urban Fagerholm
Scientific publications 17 August 2022 Advances in predictions of oral bioavailability of candidate drugs in man with new machine learning methodology Fagerholm, Hellberg and Spjuth. Molecules 26:2572, 2021. https://pubmed.ncbi.nlm.nih.gov/33925103/ Urban Fagerholm
Scientific publications 17 August 2022 Brist på riktlinjer hindrar alternativa metoder att slå igenom Fagerholm, Hellberg, Alsenius och Cederlöf. Debattartikel i tidningen Curie 210831. https://www.tidningencurie.se/debatt/brist-pa-riktlinjer-hindrar-alternativa-metoder-att-sla-igenom/ Urban Fagerholm
Scientific publications 17 August 2022 Authority publications about reduction of animal testing Netherlands initiative to reduce animal testing https://english.ncadierproevenbeleid.nl/latest/news/16/12/15/ncad-opinion-transition-to-non-animal-research FDAs initiative to reduce animal testing https://www.fdanews.com/articles/182663-congress-pushes-for-in-silico-trials-modeling Urban Fagerholm